Booster of COVID-19 vaccine administered six months after two-dose regimen of BNT162b2, shows substantial increase in antibody and T-cell responses – Johnson & Johnson

Johnson & Johnson announced preliminary results from an independent study, including a subset of participants from the Janssen-sponsored COV2008 study, conducted by Dan Barouch, M.D., Ph.D., et al. of Beth Israel Deaconess Medical Center (BIDMC), which showed that a booster shot of the Johnson & Johnson COVID-19 vaccine (Ad26.COV2.S), administered at six months after a two-dose primary regimen of BNT162b2, […]

Nucala is the first and only anti-IL-5 add-on treatment approved in Canada that targets eosinophilic inflammation in adults with chronic rhinosinusitis with nasal polyps – GSK

Nucala (mepolizumab) is now approved in Canada as an add-on maintenance treatment with intranasal corticosteroids in adult patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) inadequately controlled by intranasal corticosteroids alone. This is the fourth approved indication for Nucala for Canadian patients with eosinophilic driven diseases and is the first and only anti-IL-5 add-on treatment that targets eosinophilic inflammation […]

Does Holiday Heart Syndrome, which affects the atria, extend to the ventricles?

In an extensive study of more than 400,000 individuals, investigators found no association between alcohol consumption and ventricular arrhythmias, although higher spirit intake was associated with increasing risk, finds a new report in Heart Rhythm. Philadelphia, December 21, 2021 — The relationship between alcohol and atrial fibrillation has long been referred to as the Holiday Heart Syndrome. An extensive study of the relationship […]

COVID-19 At-Home Test granted FDA Emergency Use Authorization to expand access to rapid self-testing solutions in the United States – Roche

Roche has announced that the FDA has granted Emergency Use Authorization (EUA) for its COVID-19 At-Home Test. The test uses a simple anterior nasal swab sample that can be conveniently self-collected and self-tested by individuals aged 14 years and older, and by an adult for children aged 2-13 years old. The test is able to produce accurate, reliable and quick […]

New resistance-busting antibiotic combination could extend the use of ‘last-resort’ antibiotics

Scientists have discovered a new potential treatment that has the ability to reverse antibiotic resistance in bacteria that cause conditions such as sepsis, pneumonia, and urinary tract infections. Carbapenems, such as meropenem, are a group of vital often ‘last-resort’ antibiotics used to treat serious, multi-drug resistant infections when other antibiotics, such as penicillin, have failed. But some bacteria have found […]

Identifying rare disease-associated genetic variants in patients with severe schizophrenia

New research published in the Proceedings of the National Academy of Sciences shows that examining genetic mutations in individuals with severe schizophrenia can improve the ability to detect disease-associated rare genetic variants. The research was conducted at Columbia University Irving Medical Center and led by Dr. Anthony Zoghbi, now assistant professor of molecular and human genetics and psychiatry and behavioral sciences at […]

Radiation monotherapy shows efficacy for treating oligometastatic renal cell carcinoma

Radiation monotherapy is an effective noninvasive treatment for oligometastatic renal cell carcinoma (RCC), researchers reported on Oct. 28, 2021 in The Lancet Oncology. “These findings are exciting because we’re challenging the dogma in radiation oncology that RCC is biologically radioresistant,” said investigator Chad Tang, M.D., Assistant Professor of Radiation Oncology, University of Texas M.D. Anderson Cancer Center in Houston.  “Our strategy to […]

Experimental gene therapy reverses sickle cell disease for years

A study of an investigational gene therapy for sickle cell disease has found that a single dose restored blood cells to their normal shape and eliminated the most serious complication of the disease for at least three years in some patients. Four patients at NewYork-Presbyterian/Columbia University Irving Medical Center participated in the multicenter study, the first to report on such […]

Supermeres’ may carry clues to cancer, Alzheimer’s disease and COVID-19

Researchers at Vanderbilt University Medical Center have discovered a nanoparticle released from cells, called a “supermere,” which contains enzymes, proteins and RNA associated with multiple cancers, cardiovascular disease, Alzheimer’s disease and even COVID-19. The discovery, reported in Nature Cell Biology, is a significant advance in understanding the role extracellular vesicles and nanoparticles play in shuttling important chemical “messages” between cells, both […]