Analyses published in NEJM of a third booster shot of the Comirnaty messenger RNA vaccine from Pfizer

Publication of two separate analyses in The New England Journal of Medicine comes before a meeting of FDA advisers to discuss Pfizer’s application for authorization of a third shot of Comirnaty. The larger dataset published in NEJM comes from an analysis of more than 1 million people in Israel aged 60 or older who received at least two doses of […]

7 Toxic Things You Don’t Realize You’re Doing Because You’re Afraid Of Being Single Forever

  It’s an understatement to say our society is obsessed with romance and coupledom. Many holidays have been invented to celebrate romantic r…  It’s an understatement to say our society is obsessed with romance and coupledom. Many holidays have been invented to celebrate romantic relationships and policies made to encourage getting married and having children. Single people constantly have to dodge curious […]

Adjuvant anti-inflammatory baricitinib reduces mortality in COVID-19

Addition of baricitinib to standard of care (including dexamethasone and remdesivir) was associated with reduced mortality among hospitalized adults with COVID-19, researchers reported on Sept. 1, 2021 in the Lancet Respiratory Medicine. “In this phase 3 trial, baricitinib administered in addition to standard of care (which predominantly included dexamethasone) did not reduce the incidence of a composite endpoint of disease […]

Brain refreshing: Why the dreaming phase matters

Scientists have long wondered why almost all animals sleep, despite the disadvantages to survival of being unconscious. Now, researchers led by a team from the University of Tsukuba have found new evidence of brain refreshing that takes place during a specific phase of sleep: rapid eye movement (REM) sleep, which is when you tend to dream a lot. Previous studies […]

SOPHIA Phase III study of Margenza announces final OS data in HER2-positive breast cancer patients – MacroGenics

MacroGenics announced the final overall survival (OS) results of the SOPHIA Phase III study of Margenza (margetuximab-cmkb) in adult patients with metastatic HER2-positive breast cancer. The final OS analysis of the SOPHIA study was performed after 385 OS events occurred in the intent-to-treat (ITT) population. As per the study protocol, OS was defined as the number of days from randomization […]

Plant-based diet associated with lower risk of covid infection and less severe disease

In a recent study led by researchers at Massachusetts General Hospital (MGH) and Kings College Hospital published in Gut, people whose diets were based on healthy plant-based foods had lower risks of covid infection and severe disease.1 The beneficial effects of diet on COVID-19 seemed especially relevant in individuals living in areas of high socioeconomic deprivation. Poor metabolic health and […]

Statistical model defines ketamine anesthesia’s effects on the brain

By developing the first statistical model to finely characterize how ketamine anesthesia affects the brain, a team of researchers at MIT’s Picower Institute for Learning and Memory and Massachusetts General Hospital have laid new groundwork for three advances: understanding how ketamine induces anesthesia; monitoring the unconsciousness of patients in surgery; and applying a new method of analyzing brain activity. Based […]

Stem-like T cells could aid immunotherapy in cancer treatment

In a new study by Yale Cancer Center, researchers show stem-like T cells within certain lymph nodes could be natural cancer fighters. Targeting these T cells, which are a type of white blood cells, with immunotherapy drugs could increase the number of cancer patients that respond to treatment. The findings were reported online today in the journal Science Immunology. “Therapies that […]