Exercise likely to be best treatment for depression in coronary heart disease

A study by RCSI indicates that exercise is probably the most effective short-term treatment for depression in people with coronary heart disease, when compared to antidepressants and psychotherapy or more complex care. The study, led by researchers at RCSI University of Medicine and Health Sciences, is published in the June edition of Psychosomatic Medicine. This is the first systematic review to […]

Protecting the intellectual abilities of people at risk for psychosis

Université de Genève One person in 2000 suffers from a microdeletion of chromosome 22 that can lead to the development of psychotic disorders, such as schizophrenia, in adolescence. In addition to symptoms such as hallucinations or delusions, psychotic disorders also comes with a progressive decline in intelligence quotient (IQ). If current drug treatments are successful in containing psychotic symptoms, nothing […]

Antibody-targeted immunotoxins could help treat liver fibrosis

University of California – San Diego In mouse models of human disease, immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis. Effectively, this represents the use of an antibody-drug conjugate to target a feature of diseased tissue, an approach that is already in use in the management of solid tumours. Chronic alcohol […]

Hospitals prevent deadly fungal infection during pandemic

As COVID-19 infections threatened to overwhelm hospitals in March 2020, infection control specialists worried not just about SARS-CoV-2 but also about other viral, bacterial and fungal diseases. C. auris is a type of fungus that causes severe, often fatal infections and is resistant to most antifungal drugs. It can be carried on a patient’s skin and can survive on surfaces for […]

EMA boost for COVID-19 vaccine production

The European Medicines Agency has approved additional manufacturing capacity for two companies producing vaccines against COVID-19. The news comes as European countries continue to roll out vaccines amid rising rates of the delta variant of the virus. The medicines watchdog, which has played a leading role in approving vaccines and inspecting manufacturing facilities, gave the green light to a site […]

Positive new data for Johnson & Johnson single-shot COVID-19 vaccine on activity against Delta variant and long-lasting durability of response

Johnson & Johnson announced data that demonstrated its single-shot COVID-19 vaccine generated strong, persistent activity against the rapidly spreading Delta variant and other highly prevalent SARS-CoV-2 viral variants. In addition, the data showed that the durability of the immune response lasted through at least eight months, the length of time evaluated to date. The two preprint study summaries have been […]

A step forward for IVF patients with low success rates

Fertility patients who have a poor response to ovarian stimulation represent a stubborn challenge in IVF. Few eggs are collected, success rates are low, and several treatments are usually needed to achieve pregnancy. Some patients eventually abandon treatment without success. Now, however, a study assessing two cycles of ovarian stimulation and two egg collections in the same menstrual cycle may […]

EMA gives green light for 8 new medicines

The European Medicine Agency’s key decision-making committee on human medicines (CHMP), has recommended eight medicines for approval at its June meeting.  The Committee recommended granting a conditional marketing authorisation for Abecma (idecabtagene vicleucel) for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least three previous therapies, and whose cancer has worsened since receiving the last treatment. […]

EMA reports big wins for small pharma

The success rate for marketing authorisation applications for small and medium-sized enterprises (SMEs) has doubled between 2016 and 2020, according to the European Medicines Agency (EMA). In 2016, 40% of medicines with an SME applicant received a positive opinion. In 2020, the number had increased to 89%. In 2020 alone, SMEs were behind 16 recommendations for approval of a new […]

Public health risk from multidrug-resistant bacteria in dog food

European Society of Clinical Microbiology and Infectious Diseases Research presented by Dr Ana R. Freitas, and colleagues from UCIBIO, Faculty of Pharmacy, University of Porto, Portugal, showed that dog food from supermarkets and pet shops was a major source of antibiotic-resistant bacteria, making it an international public health risk. With some of the multidrug-resistant bacteria in raw dog food identical […]