Deadly anthrax toxin blocks multiple types of pain in mice, study shows. Anthrax has a scary reputation. Widely known to cause serious lung infections in humans and unsightly, albeit painless, skin lesions in livestock and people, the anthrax bacterium has even been used as a weapon of terror. Now the findings of a new study suggest the dreaded microbe also […]
Breast milk is the first food that babies consume. Various studies have suggested that the “taste experience” in early childhood influences eating behavior in adults. Unlike standardized infant formula, natural milk does not taste and smell the same every day. The differences are largely due to the maternal diet. No one-to-one transfer However, the taste and aroma of food consumed […]
Researchers have solved a decade-long mystery about a critical protein linked to Parkinson’s disease that could help to fast-track treatments for the incurable disease. The research, published in Nature, has for the first time produced a ‘live action’ view of the protein, called PINK1, in exquisite molecular detail. The discovery explains how the protein is activated in the cell, where it […]
The threat of antimicrobial resistance (AMR), whereby antibiotics not longer work well on bacterial illness, is a slow-burning pandemic with the potential to eclipse even the worst of the COVID-19 outbreak. In a worst-case scenario, where vital antibiotics are rendered useless, modern medicine could be plunged back into the dark ages when minor infections were life-threatening, and all surgery was […]
Stem cells have promised to be the catalyst for major strides in medical research for decades. While progress in some fields has been slower than initially hoped, scientists say advances in cell transplantation techniques are raising the prospect of curing patients with acute myeloid leukaemia (AML). In a new paper published in Leukemia, researchers from Osaka University compared two strategies […]
The FDA has approved Dupixent (dupilumab), from Sanofi + Regeneron, as an add-on maintenance treatment of patients aged 6 to 11 years with moderate-to-severe asthma characterized by an eosinophilic phenotype or with oral corticosteroid-dependent asthma. The FDA approval is based on data from a Phase III randomized, double-blind, placebo-controlled trial that evaluated the efficacy and safety of Dupixent combined with […]
ViiV Healthcare, the global specialist HIV company majority-owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, has announced it has made a regulatory submission to the FDA for approval of a new dispersible tablet formulation of the fixed dose combination of abacavir, dolutegravir and lamivudine and, to extend its current approval for Triumeq (abacavir/ dolutegravir/ lamivudine) to lower […]
Endo International announced that new post-hoc data from two Phase III studies of Xiaflex (collagenase clostridium histolyticum, or CCH) in treating men with Peyronie’s disease (PD) will be presented in an oral presentation during the Sexual Medicine Society of North America (SMSNA) annual meeting. A post-hoc analysis of pooled data from two randomized, double-blind, placebo-controlled studies Phase III trials was […]
The brain has a natural protective mechanism against Alzheimer’s disease, and researchers at Baylor College of Medicine, Texas Children’s Hospital and collaborating institutions have discovered that gene variants associated with risk of developing the disease disturb the protective mechanism in ways that can lead to neurodegeneration. The researchers also showed in a fruit fly model of the condition that a […]
Pfizer announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending the 100 mg and 200 mg doses of Cibinqo (abrocitinib), an oral, once-daily, Janus kinase 1 (JAK1) inhibitor, for marketing authorization to treat moderate to severe atopic dermatitis (AD) in adults who are candidates for systemic therapy. The […]
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