Findings suggest way to help patients heal from life-threatening C. difficile. New research from the University of Virginia School of Medicine sheds light on why a fecal transplant can benefit patients with dangerous recurrent C. difficile infections — and suggests a way to improve patient outcomes. difficileinfection causes life-threatening diarrhea, and it often takes hold in patients in hospitals and nursing homes […]
Deciphera Pharmaceuticals announced that the European Commission (EC) has approved Qinlock (ripretinib) in the European Union (EU) for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with three or more kinase inhibitors, including imatinib. The Qinlock approval was supported by efficacy results from the primary analysis of the pivotal Phase III INVICTUS […]
Phages are viruses that infect bacteria and can also be used to treat human infections. However, as with antibiotics, bacteria can readily evolve resistance to phage attack, highlighting a key limitation to the use of phages as therapeutics. Now, researchers from Yale University have shown that the naturally occurring phage A1-1 kills Shigella flexneri, a major cause of dysentery in sub-Saharan […]
First microfluidic organ-on-a-chip model of the disease could help bring much needed drugs, and personalized medicine approaches to patients. The inherited progressive disorder cystic fibrosis (CF) causes severe damage to the lungs, and other tissues in the body by affecting the cells that produce mucus, sweat, and digestive juices. In individuals carrying mutations in the cystic fibrosis transmembrane conductance regulator […]
The intestine is essential for maintaining our energy balance and is a master at reacting quickly to changes in nutrition and nutrient balance. It manages to do this with the help of intestinal cells that among other things are specialized in the absorption of food components or the secretion of hormones. In adult humans, the intestinal cells regenerate every five […]
Of two major weight-loss surgeries, sleeve gastrectomy is safer long-term than gastric bypass, researchers reported on Oct. 6, 2021 in JAMA Surgery. But sleeve gastrectomy is associated with a higher long-term risk of need for surgical revision. “It’s really important for patients to understand the risk of significant issues like death, complications, and hospitalization after these two procedures because that […]
Celltrion Healthcare announced two data sets relating to the use of the subcutaneous formulation of infliximab, Remsima SC (CT-P13 SC), in inflammatory bowel disease (IBD). The first study investigated clinical impact of switching from intravenous (IV) to subcutaneous (SC) treatment of infliximab in patients with Crohn’s disease (CD) or ulcerative colitis (UC) from the pivotal randomised controlled trial of CT-P13 […]
Deciphera Pharmaceuticals, Inc. announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending the approval of Qinlock (ripretinib) for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with three or more kinase inhibitors, including imatinib. “The majority of GIST patients who […]
The Translational Genomics Research Institute Findings of a nationwide study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that a family’s socio-economic status (SES) may influence children’s composition of gut microbiome — the mix of microscopic organisms within the digestive tract. SES includes economic resources such as education, income and occupation, and are […]
Deciphera Pharmaceuticals, Inc. announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending the approval of Qinlock (ripretinib) for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with three or more kinase inhibitors, including imatinib. The positive CHMP opinion is a […]
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