August 21, 2022

Obscure gastrointestinal bleeding: rebleeding rates and rebleeding predictors found

Obscure gastrointestinal bleeding (OGIB) is defined as gastrointestinal bleeding from a source that cannot be determined even after upper or lower gastrointestinal endoscopy is performed. It is an intractable disease that can cause repeated bloody stools and anemia without an identifiable cause, and may require frequent blood transfusions. Although the pathogenesis of OGIB remains largely unclear, it is assumed that […]

admin Health 0 1 min read
August 8, 2022

Inflammatory bowel disease increases risks for pregnant women

Pregnant women with inflammatory bowel disease (IBD) and their babies face increased risks and complications compared to pregnant women without IBD. Those are the findings from a new University of Missouri School of Medicine study that examined outcomes of more than 8 million pregnancies. IBD is a term used for Crohn’s disease and ulcerative colitis, which are characterized by chronic […]

admin Health 0 1 min read
July 25, 2022

Antibiotics affect male and female gut microbiomes differently

In a new study, researchers at Cedars-Sinai found that antibiotics have sex-specific effects on the gut microbiome makeup of male and female laboratory rats. The findings, published in the journal Frontiers in Microbiology, could have implications for using the drugs in humans to treat or prevent bacterial infection. “We found that giving the rats a multidrug antibiotic cocktail resulted in significant […]

admin Health 0 2 min read
July 10, 2022

New study sheds light on why opioids can cause gastrointestinal problems

Opioids are the gold standard for treatment of chronic and acute pain; however, their use may result in significant gastrointestinal side effects, including nausea, vomiting, and constipation. The reasons behind these side effects are not well understood. A new study in The American Journal of Pathology, published by Elsevier, is the first report of how opioids like morphine cause gastric inflammation […]

admin Health 0 2 min read
July 3, 2022

Fragile balance in the gut

The presence of probiotics such as lactic acid bacteria changes the environment in the intestine and forces the yeast fungus Candida albicans to change its metabolism, making it less infectious. This way, probiotics can contain or prevent the spread of fungal infections in the gut. Researchers at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) […]

admin Health 0 2 min read
April 29, 2022

Gastrointestinal issues linked with anxiety, social withdrawal for kids with autism

Children with autism spectrum disorder tend to experience gastrointestinal issues, such as constipation and stomach pain, at a higher rate than their neurotypical peers. Some also experience other internalizing symptoms at the same time, including stress, anxiety, depression and social withdrawal. Until now, no studies have examined the causal relationship between gastrointestinal symptoms and internalizing symptoms. A new study at […]

admin Health 0 3 min read
April 2, 2022

Interim data from INSPIRE study of Alofisel shows clinical remission rate in Crohn’s disease – Takeda

Takeda announced the first six-month interim analysis results from INSPIRE, in which clinical remission was observed in 65% of patients in both cohorts who were evaluated at 6 months. INSPIRE is a European, observational, multicenter, post-approval, open-enrollment study (EUPAS24267) evaluating the real-world effectiveness and safety of Alofisel (darvadstrocel) in patients with Crohn’s disease (CD) and complex perianal fistulas. As of […]

admin Health 0 1 min read
March 1, 2022

MU scientist links epigenetic biomarkers to gastrointestinal issues for kids with autism

As a clinician at the University of Missouri Thompson Center for Autism and Neurodevelopmental Disorders, David Beversdorf helps patients with autism spectrum disorder (ASD), many of whom may also be struggling with gastrointestinal or digestive issues, including constipation and diarrhea. These symptoms are experienced by children with ASD at a higher rate than their neurotypical peers, although some individuals might […]

admin Health 0 2 min read
January 27, 2022

INTRIGUE Phase III study of Qinlock fails to meet primary endpoint in gastrointestinal stromal tumor – Deciphera Pharmaceuticals

Deciphera Pharmaceuticals announced top-line results from the INTRIGUE Phase III clinical study of Qinlock (ripretinib) in patients with gastrointestinal stromal tumor (GIST) previously treated with imatinib. The study did not meet the primary endpoint of improved progression-free survival (PFS) compared with the standard of care. In the study, 453 patients were randomized 1:1 to either Qinlock 150 mg once daily […]

admin Health 0 50 sec read

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