Protein disguise could be new target for cancer immunotherapy

Researchers at the Francis Crick Institute have identified a protein that helps tumours evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target for future cancer treatments. A crucial part of the immune system’s response to cancer is a group of white blood cells, called CD8+ […]

Phase III TRANSFORM study of Breyanzi meets primary endpoint in large B-cell lymphoma – BMS

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Liposomal ivermectin in cancer treatment

Interview and article by Christine Clark. The anti-tumour effects of ivermectin have been described in the literature and the liposomal delivery system developed by Mountain Valley MD could be the key to making this work in practice, according to Dennis Hancock, President and CEO of Mountain Valley MD. [embedded content] The anti-tumour effects of ivermectin have been reported in the […]

Liposomal drug delivery for ivermectin and vaccines

Interview and article by Christine Clark. Liposomal drug delivery holds out the prospect of oral drug administration without the need for water and vaccine more economical use of oral vaccines, according to Dennis Hancock, President and CEO of Mountain Valley MD. [embedded content] IvectosolTM, the solubilised form of ivermectin produced by Mountain Valley MD has been tested against three variants […]

Solubilised ivermectin improves drug delivery

Interview and article by Christine Clark. Patented solubilisation technology improves the bioavailability of oral ivermectin and makes possible the formulation of an ivermectin injection for human use, according to recent work undertaken by Mountain Valley MD in Canada.  IMI spoke to Dennis Hancock, President and CEO of Mountain Valley MD to find out more. [embedded content] Mountain Valley MD is […]

New insights into androgen’s action could boost battle against prostate cancer

Researchers at UVA Cancer Center have unveiled important new insights into how hormones known as androgens act on our cells — and the discovery could boost efforts to develop better treatments for prostate, ovarian and breast cancers. The findings shed light on how androgens interact with their receptors inside cells to affect gene activity. This process is important in both […]

Metabolic hormone ‘leptin’ linked to poor vaccine response

Reduced levels of a metabolic hormone known as leptin is linked to poor vaccine antibody responses in the general population, a University of Queensland study has found. The researchers made the discovery while investigating several cohorts’ responses to the influenza vaccine or hepatitis B vaccine pre-COVID. UQ’s Professor Di Yu identified a link between the metabolic and immune systems that […]

Liraglutide prevents accumulation of lipid linked to cardiac mortality

Researchers at the Karolinska Institutet, University of Oxford and University of Copenhagen have shown that elevated levels of lipids known as ceramides can be associated with a ten-fold higher risk of death from cardiovascular disease. Treatment with liraglutide could keep the ceramide levels in check, compared with placebo. The results have been published in the Journal of the American College […]

Simple diagnostic tool predicts individual risk of Alzheimer’s

Researchers at Lund University in Sweden have developed an algorithm that combines data from a simple blood test and brief memory tests, to predict with great accuracy who will develop Alzheimer’s disease in the future. The findings are published in Nature Medicine. Approximately 20-30% of patients with Alzheimer’s disease are wrongly diagnosed within specialist healthcare, and diagnostic work-up is even more […]

Testosterone therapy may reduce non-alcoholic fatty liver disease in obese

According to a new study, testosterone therapy may reduce non-alcoholic fatty liver disease in obese men with functional hypogonadism and type-2 diabetes. Testosterone therapy may help obese men with functional hypogonadism and type-2 diabetes reduce the prevalence of non-alcoholic fatty liver disease (NAFLD), according to a study being presented at the 23rd European Congress of Endocrinology (e-ECE 2021), (http://www.ece2021.org). The […]