Multiple diagnoses are the norm for mental illness; A new genetic analysis helps explain why

More than half of people diagnosed with one psychiatric disorder will be diagnosed with a second or third in their lifetime. About a third have four or more. This can make treatment challenging and leave patients feeling unlucky and discouraged. But a sweeping new analysis of 11 major psychiatric disorders offers new insight into why comorbidities are the norm, rather […]

How can mental health professionals open their minds to psychosis?

Effective clinical care for patients with psychosis means understanding the ‘lived experience’ of their delusions, say researchers at the Universities of Birmingham, York and Melbourne. By understanding the intricacies of feelings, attitudes, and experiences which are interlinked with delusions, clinicians will be better able to build trust and genuine engagement with patients. In a new study, published today (4 May […]

Just over half of Michigan pharmacies offer overdose-fighting naloxone without prescription

Despite the ability of any Michigan pharmacy to dispense medication to combat opioid overdose without writing prescriptions, slightly more than half of pharmacies in the state offer the drug in such a way. The standing order for naloxone, commonly known as Narcan, was passed by the Michigan legislature in 2016. This allows any pharmacist to dispense the overdose reversal drug without […]

Differences in children’s behavior predict midlife health behaviors, study finds

A recent study by the Faculty of Sport and Health Sciences at the University of Jyväskylä and the Gerontology Research Center (Finland) investigated the paths from childhood socioemotional behaviour to midlife health behaviour decades later. Socioemotional behaviour at age 8 predicted health behaviour both directly and indirectly through education. There are a wide variety of factors behind health behaviour and […]

Psychiatric symptoms in Alzheimers disease

In addition to memory problems and other cognitive symptoms, most people with Alzheimer’s disease also suffer from mental health issues. It has long been unclear whether these occur because of tissue changes in the brain, or whether they represent psychological reactions to cognitive symptoms. A study from Lund University in Sweden has provided new insight, and is published in Biological Psychiatry. […]

A drug that treats alcoholism may be the next anti-anxiety medication

Alcoholism, if left untreated, could have dangerous repercussions. Thus, it is no surprise that there are a range of drugs developed to treat this condition. Of these drugs, disulfiram (DSF) is approved by the Food and Drug Agency (FDA) for the treatment of alcoholism. DSF primarily inhibits the enzyme aldehyde dehydrogenase (ALDH), which is responsible for the metabolism of alcohol. […]

MU scientist links epigenetic biomarkers to gastrointestinal issues for kids with autism

As a clinician at the University of Missouri Thompson Center for Autism and Neurodevelopmental Disorders, David Beversdorf helps patients with autism spectrum disorder (ASD), many of whom may also be struggling with gastrointestinal or digestive issues, including constipation and diarrhea. These symptoms are experienced by children with ASD at a higher rate than their neurotypical peers, although some individuals might […]

Update on the phase IV confirmatory study of Aduhelm for Alzheimer’s disease – Biogen + Eisai

Biogen Inc. and Eisai Co., Ltd. provided an important update on the continuing progress of the Phase IV post-marketing confirmatory study of Aduhelm (aducanumab-avwa) 100 mg/mL injection for intravenous use in Alzheimer’s disease. The companies anticipate submitting the final protocol for review to the FDA in March 2022, with the initiation of patient screening in May 2022. The study is […]

‘Surprisingly simple’ arithmetic of smell

Adding and subtracting certain neurons tells researchers whether or not a locust can smell an odor. Smell it inside or outside; summer or winter; in a coffee shop with a scone; in a pizza parlor with pepperoni — even at a pizza parlor with a scone! — coffee smells like coffee. Why don’t other smells or different environmental factors “get […]

Neuroprotective mechanism altered by Alzheimer’s disease risk genes

The brain has a natural protective mechanism against Alzheimer’s disease, and researchers at Baylor College of Medicine, Texas Children’s Hospital and collaborating institutions have discovered that gene variants associated with risk of developing the disease disturb the protective mechanism in ways that can lead to neurodegeneration. The researchers also showed in a fruit fly model of the condition that a […]