Simple nasal spray significantly reduces snoring and breathing difficulties in children

A simple nasal spray significantly reduced snoring and breathing difficulties in children and halved the number needing to have their tonsils removed, according to a new study. The research, led by the Murdoch Children’s Research Institute and published in JAMA Pediatrics, found a saline (salt water) nasal spray was just as effective as an anti-inflammatory steroid nasal spray at easing sleep disordered breathing […]

1 billion + young people potentially at risk of hearing loss from headphones, earbuds, loud music venues

More than 1 billion teens and young people are potentially at risk of hearing loss because of their use of headphones and earbuds and attendance at loud music venues, concludes a pooled data analysis of the available evidence, published in the open access journal BMJ Global Health. Governments around the world need to urgently prioritise ‘safe listening’ policies to safeguard aural […]

New nasal vaccine strategy could improve COVID-19 protection

Researchers from the Centenary Institute and the University of Sydney have developed a new nasal vaccination strategy that induces potent lung immunity and protection against the SARS-CoV-2 coronavirus. The new vaccine approach has been tested successfully in mice and has the potential to be a powerful tool for enhancing protection against COVID-19 infection and minimising ongoing viral spread. Made up […]

Rheumatic fever and household overcrowding

Research led by the University of Otago in New Zealand has uncovered the strongest evidence yet that household overcrowding is a major risk factor for acute rheumatic fever and streptococcal infections of the skin. Their research is published in two companion articles in the international medical journal The Lancet Regional Health — Western Pacific. Lead researcher Professor Michael Baker of the […]

AI model outperforms clinicians in diagnosing pediatric ear infections

An artificial-intelligence (AI) model built at Mass Eye and Ear was shown to be significantly more accurate than doctors at diagnosing pediatric ear infections in the first head-to-head evaluation of its kind, a research team working to develop the model for clinical use reported. According to a new study published August 16 in Otolaryngology–Head and Neck Surgery, the model, called OtoDX, […]

Breakthrough in search for tinnitus cure

After 20 years searching for a cure for tinnitus, researchers at the University of Auckland are excited by ‘encouraging results’ from a clinical trial of a mobile-phone-based therapy. The study randomised 61 patients to one of two treatments, the prototype of the new ‘digital polytherapeutic’ or a popular self-help app producing white noise. On average, the group with the polytherapeutic […]

New tool to create hearing cells lost in aging

Hearing loss due to aging, noise and certain cancer therapy drugs and antibiotics has been irreversible because scientists have not been able to reprogram existing cells to develop into the outer and inner ear sensory cells — essential for hearing — once they die. But Northwestern Medicine scientists have discovered a single master gene that programs ear hair cells into […]

New COVID-19 nasal spray outperforms current antibody treatments in mice

A new protein-based antiviral nasal spray developed by researchers at Northwestern University, University of Washington and Washington University at St. Louis is being advanced toward Phase I human clinical trials to treat COVID-19. Designed computationally and refined in the laboratory, the new protein therapies thwarted infection by interfering with the virus’ ability to enter cells. The top protein neutralized the […]

CHMP recommends Opdivo + Yervoy for first line treatment of metastatic esophageal squamous cell carcinoma – BMS

Bristol Myers Squibb announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended approval of Opdivo (nivolumab) plus Yervoy (ipilimumab) for the first-line treatment of adults with unresectable advanced, recurrent or metastatic esophageal squamous cell carcinoma (ESCC) with tumor cell PD-L1 expression greater than 1%. The European Commission (EC), which has […]