Additional COVID vaccine helps protect transplant patients

Additional booster doses of vaccine against COVID-19 are particularly important for those who are immunosuppressed, namely those who have had solid organ transplants, a new study shows. The study, published in the Journal of Infectious Diseases, shows that even after vaccination, patients taking immunosuppressive medications to prevent rejection of an organ transplant have higher risk for severe COVID-19 than those with […]

Pilot study suggests artificial intelligence could help assess, improve heart transplant outcomes

Heart transplantation can be a lifesaving operation for patients with end-stage heart failure. However, many patients experience organ transplant rejection, in which the immune system begins attacking the transplanted organ. But detecting transplant rejection is challenging — in its early stages, patients may not experience symptoms, and experts do not always agree on the degree and severity of the rejection. […]

Positive early access decision by French Haute Autorité de Santé to use Idefirix as desensitization treatment for highly sensitized kidney transplant patients – Hansa Biopharma AB

Hansa Biopharma AB, the pioneer in enzyme technology for rare immunological conditions, announced that its first-in-class treatment Idefirix (imlifidase) has been granted early access post marketing authorization (Autorisation d’accès précoce) in France by French HAS (Haute Autorité de Santé) for use in the desensitization of highly sensitized adult patients prior to kidney transplant, in accordance with the patient population specified […]

Racial disparities in kidney transplantation access are highest among young adults

In a retrospective study of adults initiating kidney failure treatment during 2011-2018, disparities in kidney transplantation by race were highest among patients age 22-44 years of age. Within this age group, kidney failure was treated by kidney transplantation among 10.9% of White patients but only 1.8% of Black and 4.4% of Hispanic patients. Research has shown wide racial/ethnic disparities in use […]

Creating universal blood-type organs for transplant

A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN’s Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation. This finding is an important step towards creating universal type O organs, which would significantly improve fairness in organ allocation and decrease mortality for patients […]

Incyte announces FDA approval of Jakafi for treatment of chronic graft-versus-host disease

Incyte has announced that the FDA has approved Jakafi (ruxolitinib) for treatment of chronic graft-versus-host disease (GVHD) after failure of one or two lines of systemic therapy in adult and pediatric patients 12 years and older. “GVHD is the leading cause of morbidity and mortality in patients following an allogeneic stem cell transplant, yet there historically have been limited treatment […]

Successful transplant of porcine heart into adult human with end-stage heart disease

In a first-of-its-kind surgery, a 57-year-old patient with terminal heart disease received a successful transplant of a genetically-modified pig heart and is still doing well three days later. It was the only currently available option for the patient. The historic surgery was conducted by University of Maryland School of Medicine (UMSOM) faculty at the University of Maryland Medical Center (UMMC), […]

Fecal transplant discovery could improve care for dangerous infections

Findings suggest way to help patients heal from life-threatening C. difficile. New research from the University of Virginia School of Medicine sheds light on why a fecal transplant can benefit patients with dangerous recurrent C. difficile infections — and suggests a way to improve patient outcomes. difficileinfection causes life-threatening diarrhea, and it often takes hold in patients in hospitals and nursing homes […]

Stem cell therapy as potential glaucoma treatment

Oregon Health & Science University is part of a national research project investigating stem cell therapy as a potential treatment for glaucoma, the world’s second leading cause of blindness. With support from the National Institutes of Health, the project is studying human stem cells that are made into retinal ganglion cells, neurons involved in sight that are damaged by glaucoma. The research […]

Transplants for alcohol-related liver inflammation surge during pandemic

The increased number of deceased donor liver transplants related to alcoholic hepatitis — up more than 50 percent over predicted numbers — was associated with rising alcohol sales. Registrations for the national organ transplant waiting list related to alcoholic hepatitis as well as the number of deceased donor liver transplants for the inflammatory liver condition rose significantly during the pandemic, […]