Hundreds of thousands of Americans with heart failure are sick enough to benefit from a transplant, yet only around 4,000 heart transplants are performed annually. One reason for this gap is the time window during which a heart can survive outside the donor body before transplant hovers around four hours. And the longer it takes for the donor heart to […]
Donor hearts from people who were COVID-19-positive appeared to be as safe for transplantation as those from people without COVID-19, according to a short-term analysis to be presented at the American Heart Association’s Scientific Sessions 2022. The meeting, held in person in Chicago and virtually, Nov. 5-7, 2022, is a premier global exchange of the latest scientific advancements, research and evidence-based […]
A large amount of lungs donated cannot be used for transplantation. Researchers at Lund University in Sweden and Skåne University Hospital have conducted an animal study bringing hope that more donor lungs could be used in the future. The researchers have launched a pilot study to investigate whether the treatment will have the same positive effects on human beings. About […]
Do pediatric kidney transplant patients have better long-term outcomes when their kidney comes from living, biologically unrelated donors compared to deceased donors? A new UC Davis Health study finds that they do. The study reviewed data from the Organ Procurement & Transplantation Network database from Jan. 1, 2001 to Sept. 30, 2021. Researchers compared the rates of graft failure (when the organ is rejected by the […]
Although kidney transplantation is the most effective treatment for children with kidney failure, rejection of the transplanted organ by the recipient’s immune system is a major concern. Transplant recipients must take life-long immunosuppressant drugs, most commonly tacrolimus, and some patients experience large fluctuations in blood levels of tacrolimus even when the dose is unchanged—a phenomenon called high tacrolimus intrapatient variability. […]
Organ transplant recipients take life-long immunosuppressive drugs to prevent their bodies from mounting an immune response against the donated organ, yet a substantial number of them still reject the organs. A new study by researchers from the University of Chicago shows that transplant recipients also mount an immune response against commensal bacteria in the organ graft, adding to the immune […]
One of the biggest concerns for patients undergoing skin grafting is scarring post-surgery and the regeneration of transplanted skin. The depth of scarring after suturing varies depending on the skill of the medical personnel performing the skin grafting, and wound healing at the suture site requires over a month. Recently, a Korean research team has drawn attention for developing a […]
Additional booster doses of vaccine against COVID-19 are particularly important for those who are immunosuppressed, namely those who have had solid organ transplants, a new study shows. The study, published in the Journal of Infectious Diseases, shows that even after vaccination, patients taking immunosuppressive medications to prevent rejection of an organ transplant have higher risk for severe COVID-19 than those with […]
Heart transplantation can be a lifesaving operation for patients with end-stage heart failure. However, many patients experience organ transplant rejection, in which the immune system begins attacking the transplanted organ. But detecting transplant rejection is challenging — in its early stages, patients may not experience symptoms, and experts do not always agree on the degree and severity of the rejection. […]
Hansa Biopharma AB, the pioneer in enzyme technology for rare immunological conditions, announced that its first-in-class treatment Idefirix (imlifidase) has been granted early access post marketing authorization (Autorisation d’accès précoce) in France by French HAS (Haute Autorité de Santé) for use in the desensitization of highly sensitized adult patients prior to kidney transplant, in accordance with the patient population specified […]
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