Study provides genetic evidence on new osteoporosis drug heart attack risk

New research highlights potential safety concerns around women taking romosozumab, a new anti-osteoporosis drug available on the NHS. The University of Bristol-led study, published in Arthritis & Rheumatology, analysed genetic data on nearly 34,000 people. Despite romosozumab being particularly effective at reducing the risk of fracture in women with severe osteoporosis, potential safety concerns following trial data suggest the drug may […]

New study questions the efficacy of many osteoarthritis treatments

Recruiting osteoarthritis patients with a lot of pain to clinical studies, may give incorrect results if the researcher does account for the natural variation in pain that occurs. A research group from Lund University in Sweden is now drawing attention to the traps in clinical studies on osteoarthritis. Osteoarthritis is a lifelong joint disease that is becoming increasingly common. The […]

Allergic (atopic) asthma/eczema linked to heightened risk of osteoarthritis

People with atopic (allergic) diseases like asthma or eczema may be at heightened risk of the painful and often disabling joint condition, osteoarthritis, finds research published online in the Annals of the Rheumatic Diseases. Drugs used to dampen down the physiological prompts for allergic reactions in the body may help lessen this risk, suggest the researchers. Osteoarthritis is the most common […]

New guideline introduces recommendations for optimal timing of elective hip or knee arthroplasty

The American College of Rheumatology (ACR) and the American Association of Hip and Knee Surgeons (AAHKS) released a summary of its new guideline titled “the Optimal Timing of Elective Hip or Knee Arthroplasty for Patients with Symptomatic Moderate to Severe Osteoarthritis or Osteonecrosis Who Have Failed Nonoperative Therapy.” The ACR and AAHKS have worked together before, creating guidelines for Perioperative Management […]

Non-surgical treatment significantly reduces knee pain for adults, especially those 50 and older

Genicular nerve radiofrequency ablation is a minimally invasive treatment for knee pain due to osteoarthritis of the knee, and can significantly reduce pain, especially for adults who are 50 and older, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Phoenix. This is the first time a study has examined patient demographics, […]

New breakthrough in the treatment of rheumatoid arthritis

A research team, led by Professor Sung Ho Park in the Department of Biological Sciences at UNIST announced the results of a study on osteoblasts that damage joint bones in patients with rheumatoid arthritis. In this study, the research team studied the possibility of a treatment method targeting mechanisms related to the differentiation process of osteoblasts that melt bones through enzyme […]

New drug offers hope for people with hand osteoarthritis

Tonia Vincent, Professor of Musculoskeletal Biology & Honorary Rheumatologist at Oxford’s Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), said: ‘Hand osteoarthritis is a common and debilitating medical condition that affects mainly women, especially around the time of the menopause. We currently have no effective treatments that modify their disease.’ The researchers started by investigating a common gene variant […]

Trial shows benefits of two forms of ankle surgery for osteoarthritis

Patients with advanced ankle osteoarthritis who undergo surgery see equally good outcomes from the two main surgical treatments for osteoarthritis, a new study led by UCL researchers has shown. The TARVA randomised clinical trial compared total ankle joint replacement with ankle fusion (when the ankle joint is pinned to prevent movement). It was led by the Comprehensive Clinical Trials Unit […]

Study examines total knee replacement in patients under 21

A new study from researchers at Hospital for Special Surgery (HSS) has evaluated trends in the use of total knee arthroplasty (TKA) in patients under 21 in the United States. The study was reported at the American College of Rheumatology (ACR) Convergence 2022 meeting (abstract number 08780). According to Cynthia A. Kahlenberg, MD, MPH, an orthopedic surgeon at HSS and a […]

Anifrolumab shows long-term promise in patients with lupus

Type I interferon (IFN) is a powerful immune activator that is present at high levels in the majority of patients with lupus, an autoimmune disease. In Arthritis & Rheumatology, researchers report positive results from the first placebo-controlled long-term trial of anifrolumab—a human monoclonal antibody that targets the type I IFN receptor—in patients with lupus. In the long-term extension trial of two […]