Key protein that drives rheumatoid arthritis damage

Scientists have identified a protein known as sulfatase-2 that plays a critical role in the damage caused by rheumatoid arthritis. A chronic disease in which the immune system attacks the body’s own joint tissues, rheumatoid arthritis affects an estimated 1.5 million Americans. Published in the journal Cellular & Molecular Immunology, the discovery sheds new light on the molecular processes that drive […]

Parkinson’s protein blueprint could help fast-track new treatments

Researchers have solved a decade-long mystery about a critical protein linked to Parkinson’s disease that could help to fast-track treatments for the incurable disease. The research, published in Nature, has for the first time produced a ‘live action’ view of the protein, called PINK1, in exquisite molecular detail. The discovery explains how the protein is activated in the cell, where it […]

SOPHIA Phase III study of Margenza announces final OS data in HER2-positive breast cancer patients – MacroGenics

MacroGenics announced the final overall survival (OS) results of the SOPHIA Phase III study of Margenza (margetuximab-cmkb) in adult patients with metastatic HER2-positive breast cancer. The final OS analysis of the SOPHIA study was performed after 385 OS events occurred in the intent-to-treat (ITT) population. As per the study protocol, OS was defined as the number of days from randomization […]