Primary results of the FROZEN-AF IDE trial with the POLARx cryoablation system – Boston Scientific

– Primary results of the FROZEN-AF IDE trial with the POLARx Cryoablation System :Results from the global, prospective, non-randomized, single-arm FROZEN-AF IDE study of the POLARx Cryoablation System met the safety and effectiveness endpoints of the trial. The study, which examined use of the device for the treatment of patients with paroxysmal, or intermittent atrial fibrillation (AF), included an extension […]

FDA approval for Inpefa to treat heart failure – Lexicon Pharma

Lexicon Pharmaceuticals, Inc. announced that the FDA has approved Inpefa (sotagliflozin), a once-daily oral tablet to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with: heart failure or type 2 diabetes mellitus, chronic kidney disease, and other cardiovascular risk factors. The broad label encompasses heart failure patients across the full range […]

Previous smallpox vaccine provides immunity to mpox

Vaccines against smallpox given until the mid-1970s offer continuing cross-reactive immunity to mpox (previously known as monkeypox), researchers from Karolinska Institutet in Sweden report in a study published in the scientific journal Cell Host & Microbe. During last year’s mpox outbreak, the virus spread for the first time outside Africa, causing over 85,000 cases of the disease to date. Men who […]

Drug significantly reduces chorea symptoms in patients with Huntington’s disease

The drug valbenazine statistically improves chorea, a movement disorder commonly associated with Huntington’s disease, when compared to a placebo, according to a recent international study led by UTHealth Houston researcher Erin Furr Stimming, MD, who served as principal investigator on behalf of the KINECT-HD Huntington Study Group. The study results – which were published online today and will appear in the June 2023 print […]

Statins associated with lower risk of stroke in patients with atrial fibrillation

Statin therapy appears to reduce the risk of stroke or transient ischemic attack in patients with atrial fibrillation, and longer use gives more protection. The findings were presented on April 16, 2023 at EHRA 2023, the annual congress of the European Heart Rhythm Association (EHRA), a branch of the European Society of Cardiology (ESC). “Our study indicates that taking statins […]

Diabetes drugs associated with fewer adverse cardiac events

GLP1 receptor agonists — a class of diabetes medications — are associated with fewer major adverse cardiovascular events than another type of diabetes drug (DPP4 inhibitors) in older veterans with no prior heart disease. The findings, reported May 9 in Annals of Internal Medicine, will aid clinicians in choosing a diabetes drug regimen for older patients. “We believe this study is […]

A new method to test cancer drug toxicity

For people with cancer, chemotherapy saves lives, but for some patients, the treatment comes with a side effect—heart damage. Screening cancer drugs for cardiotoxicity has been an ongoing challenge as heart cells don’t naturally grow in a dish, requiring researchers to do this critical testing using cardiac tissue from rodent models. A new study from researchers at Cummings School of Veterinary […]

Diabetes drug shows promise for “blinding headache” condition

Exenatide, an injectable treatment for type 2 diabetes, has shown efficacy for the treatment of ‘blinding’ headaches known as idiopathic intercranial hypertension (IIH). Researchers from a phase 2 trial reported the finding on March 12, 2023 in the journal Brain. Lead investigator Alex Sinclair, Professor of Neurology in the Institute of Metabolism and Systems Research at the University of Birmingham […]

Placebo added to methadone increases opioid treatment adherence

Researchers report that patients who knowingly took a “sugar pill” placebo along with daily methadone treatment achieved significantly higher 90-day adherence to treatment for opioid abuse disorder than patients using only methadone. The findings were published on April 12 in JAMA Network Open. “The clinical implications of our intervention have great potential impact, as retention in treatment is a serious […]

Study finds “important shortcomings” in official cancer drug information

Important information about cancer drug benefits, and related uncertainties, is frequently omitted from official prescription drug information sources for clinicians and patients in Europe, finds an analysis published by The BMJ today. Despite the commitment of medicines regulators to shared decision making and person centred care, the researchers say better information on the benefits and potential harms of medicines are needed to […]