Galapagos concludes strategic evaluation and signs letter of intent to transfer Jyseleca business to Alfasigma

Galapagos NV and Alfasigma S.p.A. announced that they have signed a letter of intent contemplating a transfer of the Jyseleca business to Alfasigma, including the European and UK Marketing Authorizations, the commercial, medical and development activities for Jyseleca and approximately 400 positions in 14 European countries. In the contemplated transaction, Galapagos will receive a €50 million upfront, potential milestone payments […]

Common drug can improve hand osteoarthritis symptoms: Study

Relief could be on the way for people with painful hand osteoarthritis after a Monash University and Alfred Health-led study found an affordable existing drug can help. Until now there has been no effective treatment. Published in The Lancet, the paper investigated methotrexate, a low-cost, effective treatment for inflammatory joint conditions such as rheumatoid arthritis and psoriatic arthritis. It has been widely […]

New study reveals the most common form of arthritis, osteoarthritis, affects 15% of the global population over the age of 30

A new study projects nearly 1 billion people will be living with osteoarthritis, the most common form of arthritis, by 2050. Currently, 15% of individuals aged 30 and older experience osteoarthritis. The research, published today in The Lancet Rheumatology, analyzes 30 years of osteoarthritis data (1990–2020) covering more than 200 countries and was led by the Institute for Health Metrics and Evaluation […]

A commonly used tool is suboptimal in predicting osteoporosis fracture risk in younger post-menopausal women

The commonly used Fracture Risk Assessment Tool (FRAX), which includes self-identified race and ethnicity information, and the Osteoporosis Self-Assessment Tool (OST), which does not, had suboptimal performance in determining major osteoporotic fracture risk across racial/ethnic categories in younger postmenopausal women. But OST was excellent for identifying who had osteoporosis within each racial/ethnic category. BACKGROUND The researchers sought to compare the […]

Patients with rheumatic and musculoskeletal conditions vulnerable to long term opioid use

Patients with rheumatic and musculoskeletal conditions are vulnerable to long term opioid use, with up to 1 in 3 of those with rheumatoid arthritis or fibromyalgia, who take these drugs for the first time, potentially at risk, suggest the findings of a research letter, published online in the Annals of the Rheumatic Diseases. People with rheumatic and musculoskeletal conditions are often […]

Study provides genetic evidence on new osteoporosis drug heart attack risk

New research highlights potential safety concerns around women taking romosozumab, a new anti-osteoporosis drug available on the NHS. The University of Bristol-led study, published in Arthritis & Rheumatology, analysed genetic data on nearly 34,000 people. Despite romosozumab being particularly effective at reducing the risk of fracture in women with severe osteoporosis, potential safety concerns following trial data suggest the drug may […]

New study questions the efficacy of many osteoarthritis treatments

Recruiting osteoarthritis patients with a lot of pain to clinical studies, may give incorrect results if the researcher does account for the natural variation in pain that occurs. A research group from Lund University in Sweden is now drawing attention to the traps in clinical studies on osteoarthritis. Osteoarthritis is a lifelong joint disease that is becoming increasingly common. The […]

People with arthritis 20% less likely to be in work

The typical person living with arthritis in the UK is 20% less likely to be in work than their equivalent without the condition, new research shows. And the most striking finding was that non-university educated women aged 60-plus are at least 37% less likely to be in work if they have arthritis, compared to matched individuals without the condition. The […]

New drug offers hope for people with hand osteoarthritis

Tonia Vincent, Professor of Musculoskeletal Biology & Honorary Rheumatologist at Oxford’s Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), said: ‘Hand osteoarthritis is a common and debilitating medical condition that affects mainly women, especially around the time of the menopause. We currently have no effective treatments that modify their disease.’ The researchers started by investigating a common gene variant […]

Trial shows benefits of two forms of ankle surgery for osteoarthritis

Patients with advanced ankle osteoarthritis who undergo surgery see equally good outcomes from the two main surgical treatments for osteoarthritis, a new study led by UCL researchers has shown. The TARVA randomised clinical trial compared total ankle joint replacement with ankle fusion (when the ankle joint is pinned to prevent movement). It was led by the Comprehensive Clinical Trials Unit […]