New drug offers hope for people with hand osteoarthritis

Tonia Vincent, Professor of Musculoskeletal Biology & Honorary Rheumatologist at Oxford’s Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), said: ‘Hand osteoarthritis is a common and debilitating medical condition that affects mainly women, especially around the time of the menopause. We currently have no effective treatments that modify their disease.’ The researchers started by investigating a common gene variant […]

Trial shows benefits of two forms of ankle surgery for osteoarthritis

Patients with advanced ankle osteoarthritis who undergo surgery see equally good outcomes from the two main surgical treatments for osteoarthritis, a new study led by UCL researchers has shown. The TARVA randomised clinical trial compared total ankle joint replacement with ankle fusion (when the ankle joint is pinned to prevent movement). It was led by the Comprehensive Clinical Trials Unit […]

Study examines total knee replacement in patients under 21

A new study from researchers at Hospital for Special Surgery (HSS) has evaluated trends in the use of total knee arthroplasty (TKA) in patients under 21 in the United States. The study was reported at the American College of Rheumatology (ACR) Convergence 2022 meeting (abstract number 08780). According to Cynthia A. Kahlenberg, MD, MPH, an orthopedic surgeon at HSS and a […]

Anifrolumab shows long-term promise in patients with lupus

Type I interferon (IFN) is a powerful immune activator that is present at high levels in the majority of patients with lupus, an autoimmune disease. In Arthritis & Rheumatology, researchers report positive results from the first placebo-controlled long-term trial of anifrolumab—a human monoclonal antibody that targets the type I IFN receptor—in patients with lupus. In the long-term extension trial of two […]

Nerve blocks show efficacy in knee osteoarthritis

Researchers report that patients with knee osteoarthritis have achieved significant short-term pain relief with ultrasound-guided genicular nerve blocks (GNB), locally injected anesthetics that block nerves around the knee joint. The findings were published on Nov. 12, 2022 in Arthritis & Rheumatology. “This study demonstrates that genicular nerve block is an effective short-term therapy for pain management in people with knee […]

Orthopedic surgery patients do fine without opioid painkillers

Opioid-based painkillers have become a mainstay of post-operative care in orthopaedics but carry a risk of addiction. Now a new study by researchers at McMaster University and Hamilton Health Sciences (HHS), suggests patients can recover from orthopaedic surgery just as well without using opioid-based painkillers. The findings, published by the Journal of the American Medical Association (JAMA), could have positive implications […]

Therapeutic effects of conservative treatment with 2-week bed rest for osteoporotic vertebral fractures: a prospective cohort study

Aging is universal. Both osteoporosis and the bone fractures that occur as a result of osteoporosis become more likely with age. Current clinical guidelines do not recommend bed rest during treatment for osteoporotic vertebral fractures—spinal fractures that occur in bones that has been weakened by osteoporosis—because there has not been enough evidence to make conclusive recommendations. However, a recent study […]

Could blood marker predict the risk of osteoporotic hip fracture in men?

Bone health requires a balanced activity of various bone cell types including bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoporosis occurs when osteoclasts dominate without adequate bone formation to compensate. In new research published in the Journal of Bone and Mineral Research, elevated blood levels of a certain chemokine, or small signaling protein, that promotes osteoclast formation were linked with a higher risk […]

First new treatment for osteoporosis for over a decade

Thousands of people in England and Wales with severe osteoporosis who are at high risk of fracture are set to benefit from a new treatment – romosozumab (Evenity™, UCB) – after NICE recommended it for people after menopause in final draft guidance published on 1st April by NICE. Over 20,000 people could be eligible for the treatment according to the […]