Pralsetinib therapy shows high response in range of cancer patients with RET gene fusions

In a Phase I/II trial, cancer treatment with pralsetinib has produced high response rates in patients with RET gene fusions, regardless of tumor type, researchers reported on Aug.12, 2022 in Nature Medicine. “We’ve had an explosion in clinical next-generation sequencing that allows us to understand shared biomarkers across multiple tumor types, and this study was important to determine if RET fusions are […]

Pediatric kidney transplant patients fare better when kidney is from live donor

Do pediatric kidney transplant patients have better long-term outcomes when their kidney comes from living, biologically unrelated donors compared to deceased donors? A new UC Davis Health study finds that they do. The study reviewed data from the Organ Procurement & Transplantation Network database from Jan. 1, 2001 to Sept. 30, 2021. Researchers compared the rates of graft failure (when the organ is rejected by the […]

Exercise training program improves cardiorespiratory fitness in adults with chronic kidney disease

This randomized trial recently published in the American Journal of Kidney Diseases (AJKD) found that a 12- month program of in-center aerobic and resistance exercise program improved physical functioning among adults 55 years and older with CKD stages G3b-4 and a high level of medical comorbidities. Among adults ≥55 years with CKD stages G3b-4 and with a high level of co-morbidity, a […]

Immunosuppressive drug’s blood level variability may identify pediatric kidney transplant recipients at risk of rejection

Although kidney transplantation is the most effective treatment for children with kidney failure, rejection of the transplanted organ by the recipient’s immune system is a major concern. Transplant recipients must take life-long immunosuppressant drugs, most commonly tacrolimus, and some patients experience large fluctuations in blood levels of tacrolimus even when the dose is unchanged—a phenomenon called high tacrolimus intrapatient variability. […]

Widely-used kidney function tests underestimate scale of kidney disease

The findings suggest that methods developed in high-income settings to check kidney function are not accurate for many people in Africa. Researchers from the African Research on Kidney Disease (ARK) Consortium ran the study, which focused on more than  2 500 people in Malawi, South Africa and Uganda. About the study Testing how well kidneys function is essential to diagnosing kidney […]

Automating renal access in kidney stone surgery using AI-enabled surgical robot

Percutaneous nephrolithotomy (PCNL) is an efficient, minimally-invasive, gold standard procedure used for removing large kidney stones. Creating an access from the skin on the back to the kidney — called renal access, is a crucial yet challenging step in PCNL. An inefficiently created renal access can lead to severe complications including massive bleeding, thoracis and bowel injuries, renal pelvis perforation, […]

Combining certain meds with ibuprofen can permanently injure kidneys

Anyone who is taking a diuretic and a renin-angiotensin system (RSA) inhibitor for high blood pressure should be cautious about also taking ibuprofen, according to new research. Diuretics and RSA inhibitors are commonly prescribed together for people with hypertension and are available under various pharmaceutical brand names. Painkillers such as ibuprofen are available over-the-counter in most pharmacies and stores in […]

Researchers identify key regulators of urinary concentration in the kidney

Proper function of the kidney is critical for concentrating urine, regulating blood pressure, and for the tight control of electrolyte levels in the blood. The kidney achieves these important functions through many microscopic functional units, called nephrons. These nephrons consist of different segments with distinct functions. How these segments form during development and how their function is maintained in the […]

Kerendia approved in EU for adult patients with chronic kidney disease associated with type 2 diabetes – Bayer HealthCare

The European Commission has granted marketing authorization in the European Union (EU) for finerenone under the brand name Kerendia from Bayer HealthCare. Kerendia (10 mg or 20 mg), a non-steroidal, selective mineralocorticoid receptor antagonist, is indicated for the treatment of chronic kidney disease (stage 3 and 4 with albuminuria) associated with type 2 diabetes in adults. “Even when blood glucose […]

Saphnelo approved in the EU for the treatment of moderate to severe systemic lupus erythematosus – AstraZeneca

AstraZeneca’s Saphnelo (anifrolumab) has been approved in the European Union as an add-on therapy for the treatment of adult patients with moderate to severe, active autoantibody-positive systemic lupus erythematosus (SLE), despite receiving standard therapy. Saphnelo is the first biologic for SLE approved in Europe with an indication that is not restricted to patients with a high degree of disease activity. […]