Beyond use dating of nanoparticle albumin-bound paclitaxel (Pazenir) infusion

Prepared infusions of nanoparticle albumin-bound (nab) paclitaxel are stable for seven days, when stored in a refrigerator, according to researcher Helen Linxweiler (University Medical Centre of Johannes Gutenberg University, Mainz, Germany). Paclitaxel is widely used in cancer chemotherapy e.g. for treatment of metastatic breast, pancreas and lung cancer. The nab formulation has to be reconstituted and diluted in a carrier […]

Nanoparticle-formulated drug combination is effective in medulloblastoma, a pediatric brain tumor

UNC Lineberger Comprehensive Cancer Center researchers have demonstrated that a novel combination of two drugs that act as targeted inhibitors, delivered in a nanoparticle formulation, extend the survival of mice with medulloblastoma. The research team believes this laboratory success could be translated into a less toxic treatment for medulloblastoma, the most common malignant pediatric brain tumor. Advances such as this […]