Antibiotics after birth affects gut microbes of babies

Treating babies with antibiotics in the first week of life is linked with a decrease in healthy bacteria necessary amongst others to digest milk and an increase in antimicrobial resistance, research suggests. Experts say that clinicians should consider using antibiotics in a way that causes least harm to the newborns microbiome — the community of microbes that live in our […]

Creating universal blood-type organs for transplant

A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN’s Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation. This finding is an important step towards creating universal type O organs, which would significantly improve fairness in organ allocation and decrease mortality for patients […]

European Commission approves Vaxneuvance (pneumococcal 15-valent conjugate vaccine) for individuals 18 years of age and older – Merck Inc

Merck Inc., announced that the European Commission (EC) has approved Vaxneuvance (Pneumococcal 15-valent Conjugate Vaccine) for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae in individuals 18 years of age and older. The approval allows marketing of Vaxneuvance in all 27 European Union (EU) Member States plus Iceland, Norway and Lichtenstein. The use of […]

Can a dangerous microbe offer a new way to silence pain?

Deadly anthrax toxin blocks multiple types of pain in mice, study shows. Anthrax has a scary reputation. Widely known to cause serious lung infections in humans and unsightly, albeit painless, skin lesions in livestock and people, the anthrax bacterium has even been used as a weapon of terror. Now the findings of a new study suggest the dreaded microbe also […]

Parkinson’s protein blueprint could help fast-track new treatments

Researchers have solved a decade-long mystery about a critical protein linked to Parkinson’s disease that could help to fast-track treatments for the incurable disease. The research, published in Nature, has for the first time produced a ‘live action’ view of the protein, called PINK1, in exquisite molecular detail. The discovery explains how the protein is activated in the cell, where it […]

Embryonic cells sense stiffness in order to form the face

Cells in the developing embryo can sense the stiffness of other cells around them, which is key to them moving together to form the face and skull, finds a new study by UCL researchers. In the study of frog embryos, published in Nature, researchers found that embryonic cells can navigate away from soft regions of the embryo and toward harder regions. […]

New findings on bacteria that increase risk of pancreatic cancer

Bacteria from the digestive system seem to have the potential to cause damage to pancreatic cells, increasing the risk of malignant tumours. Now for the first time, live bacteria from cystic pancreatic lesions that are precursors to pancreatic cancer, have been analysed by researchers at Karolinska Institutet in Sweden. The study, which is published in Gut Microbes, can lead to prophylactic […]

How the superbug Pseudomonas aeruginosa reacts to antibiotics

The bacterium Pseudomonas aeruginosa is resistant to all antibiotics on the market. Therefore, there is a great need for new therapeutic approaches. In order to find them, it helps to understand how the germ reacts to active substances. Researchers at Ruhr-Universität Bochum (RUB) have studied how different drugs affect the difficult-to-treat bacterium Pseudomonas aeruginosa. According to the World Health Organisation, new […]

Phages kill dystentery-causing bacteria and reduce virulence in surviving bacteria

Phages are viruses that infect bacteria and can also be used to treat human infections. However, as with antibiotics, bacteria can readily evolve resistance to phage attack, highlighting a key limitation to the use of phages as therapeutics. Now, researchers from Yale University have shown that the naturally occurring phage A1-1 kills Shigella flexneri, a major cause of dysentery in sub-Saharan […]