Making CAR-T therapy most effective in leukaemia patients

Too many “exhausted” T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukaemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job. Now, a new study from researchers at the University of Pennsylvania shows how to overcome this type of resistance and reinvigorate these T […]