Why do up to 80 per cent of patients with bone marrow cancer (multiple myeloma) develop bone damage (osteolysis) in some regions of the body while others are spared this damage? This is a question that has not yet been sufficiently investigated. On a research stay in Buffalo, New York, the senior physician PD Dr Maximilian Merz from Leipzig was […]
A research team led by Professor Moon In-kyu of the Department of Robotics and Mechatronics Engineering at DGIST (President Kuk Yang) developed an AI holography system that automatically extracts important information and inspects the quality of red blood cells. It is expected to become a key technology that enables cleaner and healthier red blood cell injections to patients through accurate […]
Bone health requires a balanced activity of various bone cell types including bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoporosis occurs when osteoclasts dominate without adequate bone formation to compensate. In new research published in the Journal of Bone and Mineral Research, elevated blood levels of a certain chemokine, or small signaling protein, that promotes osteoclast formation were linked with a higher risk […]
Although kidney transplantation is the most effective treatment for children with kidney failure, rejection of the transplanted organ by the recipient’s immune system is a major concern. Transplant recipients must take life-long immunosuppressant drugs, most commonly tacrolimus, and some patients experience large fluctuations in blood levels of tacrolimus even when the dose is unchanged—a phenomenon called high tacrolimus intrapatient variability. […]
People with hematologic malignancies—or blood cancers including leukemia, lymphoma, and multiple myeloma—have an impaired immune system due to their disease and its treatment, putting them at risk of severe COVID-19 infection and experiencing a reduced response to COVID-19 vaccination. In a recent study published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society, less than half of patients with […]
Global Blood Therapeutics announced the European Commission (EC) has granted Marketing Authorization for Oxbryta (voxelotor) for the treatment of hemolytic anemia due to sickle cell disease (SCD) in adult and pediatric patients 12 years of age and older as monotherapy or in combination with hydroxycarbamide (hydroxyurea). Oxbryta, a once-daily, oral treatment, is the first medicine approved in Europe that directly […]
A new approach from Penn Medicine researchers could cut the time it takes to alter patients’ immune cells for infusion back into the body to find and attack cancer. The cell manufacturing process for this type of immunotherapy that was pioneered at Penn — CAR T cell therapy — typically takes nine to 14 days. In a pre-clinical study published […]
A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN’s Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation. This finding is an important step towards creating universal type O organs, which would significantly improve fairness in organ allocation and decrease mortality for patients […]
Stem cells have promised to be the catalyst for major strides in medical research for decades. While progress in some fields has been slower than initially hoped, scientists say advances in cell transplantation techniques are raising the prospect of curing patients with acute myeloid leukaemia (AML). In a new paper published in Leukemia, researchers from Osaka University compared two strategies […]
A study of an investigational gene therapy for sickle cell disease has found that a single dose restored blood cells to their normal shape and eliminated the most serious complication of the disease for at least three years in some patients. Four patients at NewYork-Presbyterian/Columbia University Irving Medical Center participated in the multicenter study, the first to report on such […]
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