Publication of two separate analyses in The New England Journal of Medicine comes before a meeting of FDA advisers to discuss Pfizer’s application for authorization of a third shot of Comirnaty. The larger dataset published in NEJM comes from an analysis of more than 1 million people in Israel aged 60 or older who received at least two doses of […]
Addition of baricitinib to standard of care (including dexamethasone and remdesivir) was associated with reduced mortality among hospitalized adults with COVID-19, researchers reported on Sept. 1, 2021 in the Lancet Respiratory Medicine. “In this phase 3 trial, baricitinib administered in addition to standard of care (which predominantly included dexamethasone) did not reduce the incidence of a composite endpoint of disease […]
Moderna, Inc., announced it has initiated its submission to the FDA for the evaluation of a booster dose of the Moderna COVID-19 vaccine (mRNA-1273) at the 50 µg dose level. The Company expects to submit data to the European Medicines Agency (EMA) and other regulatory authorities around the world in the coming days. </p. The Phase II study of mRNA-1273 […]
The European Medicines Agency has approved additional manufacturing capacity for two companies producing vaccines against COVID-19. The news comes as European countries continue to roll out vaccines amid rising rates of the delta variant of the virus. The medicines watchdog, which has played a leading role in approving vaccines and inspecting manufacturing facilities, gave the green light to a site […]
Journal of Clinical Investigation The discovery that multiciliated cells in the nasal epithelium are the first cells to be targeted in early COVID-19 infection might provide the rationale for treatment using suitable antiviral nasal sprays. Led by Director KOH Gou Young, scientists from the Center for Vascular Research within the Institute for Basic Science, South Korea, have recently uncovered the […]
Interview and article by Christine Clark. The anti-tumour effects of ivermectin have been described in the literature and the liposomal delivery system developed by Mountain Valley MD could be the key to making this work in practice, according to Dennis Hancock, President and CEO of Mountain Valley MD. [embedded content] The anti-tumour effects of ivermectin have been reported in the […]
Interview and article by Christine Clark. Liposomal drug delivery holds out the prospect of oral drug administration without the need for water and vaccine more economical use of oral vaccines, according to Dennis Hancock, President and CEO of Mountain Valley MD. [embedded content] IvectosolTM, the solubilised form of ivermectin produced by Mountain Valley MD has been tested against three variants […]
Interview and article by Christine Clark. Patented solubilisation technology improves the bioavailability of oral ivermectin and makes possible the formulation of an ivermectin injection for human use, according to recent work undertaken by Mountain Valley MD in Canada. IMI spoke to Dennis Hancock, President and CEO of Mountain Valley MD to find out more. [embedded content] Mountain Valley MD is […]
Reduced levels of a metabolic hormone known as leptin is linked to poor vaccine antibody responses in the general population, a University of Queensland study has found. The researchers made the discovery while investigating several cohorts’ responses to the influenza vaccine or hepatitis B vaccine pre-COVID. UQ’s Professor Di Yu identified a link between the metabolic and immune systems that […]
People who have had mild illness develop antibody-producing cells that can last lifetime Washington University School of Medicine Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine in St. Louis. Such cells […]
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