GLP-1 agonists such as semaglutide were developed for treatment of type II diabetes but have also been successful as weight-loss agents for non-diabetics. Many new agents are now in the pipeline. IMI spoke to Hannah Beba, Consultant Pharmacist in Diabetes, Leeds Health and Care Partnership to find out more. [embedded content] GLP-1 agonists mimic the action of the naturally-occurring incretin […]
Pharmacogenomics and personalised medicine are increasingly becoming a part of mainstream healthcare and it is an area where pharmacists have a major part to play. In this series of short videos, Raliat Onatade, Chief Pharmacist for North Thames Genomic Medicines Service Alliance, describes what has already been done and the opportunities and challenges for further development. The added value of […]
Recent research has demonstrated the value of pharmacogenomics-guided prescribing but this is a far cry from the implementation of routine services. Dr Raliate Onatade Chief Pharmacist for North Thames Genomics Medicine Service Alliance, explains what is required and the challenges that need to be addressed. [embedded content] The PREPARE (PREemptive Pharmacogenomic Testing for Preventing Adverse Drug Reactions) study assessed the […]
A number of examples show how pharmacogenetic testing is being integrated into day-to-day practice and helping to improve the safe and effective use of medicines, Raliat Onatade, Chief Pharmacist for North Thames Genomics Medicine Service Alliance, explains. [embedded content] Mitochondrial mutation The mitochondrial mutation m.1555A>G is often associated with maternally-transmitted deafness. People who carry this mutation are more likely to […]
Raliat Onatade, Chief Pharmacist for North Thames Genomic Medicines Service Alliance, recently gave the opening keynote address at the EAHP Congress in Lisbon (March 2023) on the subject of pharmacogenomics and personalised medicine. IMI spoke to her to find out more about the topic and the opportunities that it offers to hospital pharmacists in clinical practice. [embedded content] Dr Onatade’s […]
John A. Armitstead is the System Director of Pharmacy at Lee Health in Fort Myers, Florida. During the past five years, Fort Myers has twice been hit by major hurricanes (Irma in 2017, Ian in 2022), making him possibly the most hurricane-experienced pharmacy director in the United States. In this series of short videos, he describes the preparations that the […]
Professor Colleen Aldous is a research professor at in the School of Clinical Medicine at the University of Kwazulu-Natal in South Africa. She recently described the SAIVE trial of prophylactic ivermectin for covid-19 as the “best quality RCT we have yet seen published on ivermectin”. In this series of short videos, she explains what makes the SAIVE trial so good […]
A recent prospective study has shown that vitamin D supplementation has a “strongly positive effect” in reducing the incidence of rheumatoid arthritis, Martin Hewison, Professor of Molecular Endocrinology, explains. [embedded content] The recognition that low vitamin D levels were linked with increased risks of a variety of health issues, including common cancers and autoimmune disease, prompted calls for prospective, randomised, […]
Vitamin D deficiency occurs even in sunny parts of the world and one way to tackle it could be fortification of flour, a foodstuff that is used by most communities, suggests Professor of Molecular Endocrinology, Martin Hewison. [embedded content] One reason for low levels of vitamin D is limited exposure to sunlight and countries in the far North or South […]
Vitamin D has a clear role in regulating the immune/inflammatory response and association studies have demonstrated a link between vitamin D deficiency and autoimmune diseases. However, supplementation is complicated by the lack of universal agreement about the levels that are ‘normal’ and ‘deficient’, says Professor Martin Hewison. [embedded content] Vitamin D acts in both the innate and adaptive arms of […]
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