Esketamine shows higher efficacy than quetiapine in treatment-resistant depression

Researchers report that patients treated for treatment-resistant depression with esketamine NS (nasal spray), a form of ketamine, achieve better and more durable outcomes than similar patients treated with quetiapine. The findings were published on October 5 in the New England Journal of Medicine and presented the same week at the annual meeting of the European College of Neuropsychopharmacology. “This is […]

People living with HIV at substantially higher risk of depression and suicide, especially in first 2 years after diagnosis

People living with HIV (PLWH) are far more likely to be diagnosed with depression, take antidepressants, be treated with electroconvulsive therapy, and commit suicide than population controls, especially in the first two years after diagnosis, according to new research being presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark (15-18 April). The nationwide […]

Scientists explain emotional ‘blunting’ caused by common antidepressants

Scientists have worked out why common anti-depressants cause around a half of users to feel emotionally ‘blunted’. In a study published today, they show that the drugs affect reinforcement learning, an important behavioural process that allows us to learn from our environment. According to the NHS, more than 8.3 million patients in England received an antidepressant drug in 2021/22. A […]

Psychotherapy found to be ineffective or unavailable for medicated patients with severe depression

Antidepressants are the first-choice treatment for severe depression. Antidepressant use is often supplemented by psychotherapy. Now a major ongoing international study has shown that adding psychotherapy treatment to antidepressant medication does not improve treatment outcomes in severely depressed patients. The study, presented at the European Congress of Psychiatry*, also found that those patients with severe depression who were also treated […]